About us: Tentarix Biotherapeutics is an exciting company with a game-changing technology platform that allows for the discovery of next generation, multi-specific investigational drugs, called Tentacles, to address limitations of existing cancer, autoimmune and other disease therapies. 

We are led by a seasoned executive team with proven expertise in the field of multi-specific drug discovery. We are committed to hiring and retaining highly qualified and motivated team members who are passionate about making a difference for patients in the modern drug discovery landscape with our ground-breaking technology. 

Tentarix team members are creative, hands-on, self-directed, and display excellent communication skills. They also exhibit a high level of integrity, resiliency, and a determination to contribute to the success of the company. We offer autonomy, flexibility, a modern culture, and the best tools to ensure the success of our individuals and collectively.

Role:

The Senior Scientist of Pharmacology will be responsible for the assessment of engineered protein therapeutics in autoimmune/inflammatory disease mouse models and mouse models of immuno-oncology. In addition, the Senior Scientist is expected to lead, mentor and train group members and perform ex vivo and in vitro assays defining therapeutic activity and cellular selectivity. 

Responsibilities:

• Development and execution of a variety of autoimmune disease and immuno-oncology in vivo models to test engineered protein therapeutics
• Simultaneously prioritize tasks to support multiple immunology/oncology projects
• Independently perform various in vivo studies, including study design, execution, data analysis, and presentation to multidisciplinary teams and senior management
• Perform mechanistic ex vivo studies on samples harvested from mouse models of various diseases using flow cytometry, mesoscale discovery, RT-PCR, and other techniques
• Develop complex in vitro immunological assays for evaluation of mechanism of action of engineered protein therapeutics
• Build strong lines of communication with other teams at Tentarix to ensure proper hand-offs, maintain efficient workflows and maximize our capabilities
• Maintain a culture of innovation and continual improvement
• Contribute to scientific discussions, regulatory filing, and intellectual property documents

Qualifications and Skills:

• Ph.D., post-doctoral experience, and 3+ years in industry in the field of immunology with hands on experience in mouse models is a requirement
• Experience of working with biologics or other forms of immunotherapies targeting autoimmune disease or cancer is desired
• Technical experience in the development and execution of ELISAs, MSD, flow-cytometry, in vitro and ex vivo immunology assays, and/or in vivo assays
• Experience with immune cell-based assays including isolation of immune cell populations from whole blood or tissues is desired
• Experience with in vivo efficacy studies in animal models of autoimmunity or cancer (particularly PBMC engrafted NSG and/or CD34 humanized mouse models) is desirable
• Goal oriented, organized, capable of prioritizing across multiple projects, and able to execute to timelines that meet company goals
• A track record of innovation and scientific rigor, strong problem solving and troubleshooting skills, and ability to contribute constructively to discussions.
• Thrive in a cross functional team environment and committed to positively contributing to Tentarix supportive small company culture
• Excellent verbal and written communication skills
• Confident, independent and decisive; proactive and results-oriented with high performance standards
• Hands-on contributor who understands the need for involvement at all levels of activity within a small company environment
• Commitment to exhibiting the highest levels of integrity, ethics and scientific standards

Our employees are the Company’s most valuable asset, so we offer attractive compensation and benefits packages to retain the best in the field. Tentarix is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. 

The wage range for this role takes into account the wide range of factors that are considered in making compensation decisions including but not limited to skill sets, experience, training, licensure, certifications, and other business and organizational needs. The disclosed range estimate has not been adjusted for the applicable geographic differential associated with the location at which the position may be filled. At Tentarix, it is not typical for an individual to be hired at or near the top of the range for their role and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current range is $130,000 – 145,000 + bonus target + benefits + equity.

 Tentarix Biotherapeutics, Inc. also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. We are an E-Verify employer.